Yes, The 22-250 will kill deer and antelope out to 300 but closer is better. I've done it so I have some history. I've shot more 22-250 rounds than any other rifle cartridge with the exception of the 222 Rem and I still do not count the . 224 diameter calibers as big game bores.
Briefly, what is a 22 250 rifle used for? The . 22-250 Remington is a very high-velocity (capable of reaching over 4000 feet per second), short action, . 22 caliber rifle cartridge primarily used forvarmint hunting and small game hunting. Though it finds occasional use on deer, this is not recommended.
In overall, will a 22 250 kill an elk?
The 22-250 can flat out kill and kill spectacularly. I have seen it used on deer and, God forbid, elk with 55gr soft points. One of the local natural resources guy uses one. I would love to use one if it were legal here.
Can a 22 250 kill deer?
22-250 is very popular. Most lost deer are the result of poor shots, not caliber. I would give that SPS a try.
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22LR rather than as the high powered cartridge that it is, more than capable of killing 140-220lb (the weight range around here) whitetails at distances of up to at least 300 yards. Another common comment is that if you use a 22-250 you should expect to do a lot of tracking.
22-250 for across the course (high power) competition, you'll want to use the 77-80 grain boat-tail match bullets. For those, we suggest an 8-twist barrel (as long as it is a true 1:8″ twist). That will let you shoot the excellent 77gr and 80gr Sierra MatchKings, and 80gr Bergers.